Thanks for visiting us at In Cosmetics!

Thanks for visiting us at In Cosmetics!

News

    New service at Eurosafe : Evaluation of the cutaneous microbiome !

    We developed a new offer in collaboration with Vaiomer. For the launching, we interviewed them to tell you more about it. Find the interview below!

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    We are launching Wepredic !

    We are launching Wepredic! – A group that gathers key players in in vitro technologies Christophe Chesné, Ph.D, CEO of Biopredic International, is also the founder of Eurosafe, Starlight and Advancells. With their long-standing expertise in in vitro technologies for toxicology and pharmacokinetics, these companies daily help and support world’s leading pharmaceutical, cosmetic and chemical companies. Wepredic has been funded to unite these four brands and deliver in vitro testing solutions that aim to replace laboratory animals. Discover Christophe Chesné’s editorial on the reasons for this strategic move !

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    New logo and new brand identity for Eurosafe !

    As part of re-shaping the brands of the group Wepredic, our parent company, Eurosafe has been given a facelift. Our new logo captures the essence of our business activity: the safety evaluation of cosmetic and of pharmaceutical products!

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Last posters

  • In-silico modelization of compounds interaction with Bile salt Export Pump (BSEP): an alternative approach to predict hepatotoxicity

    3/15/19

    BSEP is an efflux transporter protein present in the hepatocytes membrane that plays important role in bile acid flow from hepatocyte cell into the bile canaliculi (1,2). Impaired BSEP activity due to drug interaction leads to accumulation of bile acid within the hepatocyte cells and results in cholestasis liver injury (DILI)(3). However, due to the lack of a X-ray structure of BSEP, there is no detail information about interaction of compounds with BSEP.

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  • Cosmetics exposure data - Particular case of children from birth

    3/15/19

    It is commonly accepted that the Skin Surface Area over Body weight ratio (SA/BW) of infants and children is higher as compared with that in adults. Regarding the safety assessment process of cosmetic ingredients, Toxicological Reference Values (TRV) are expressed as mg/kg bw and the change in the ratio of surface area/body weight compared with an adult would give, according to A.G. Renwick (1998), a discrepancy of 2.3-fold for children at birth (except premature infants). Such inter individual variation is already covered by the generally accepted default value of 100 calculated for individual ingredients which is composed of 10 for interspecies variations (4.0 for toxicokinetics) and 10 for human variability, covering toxicokinetic (3.2) and toxicodynamic (3.2) differences between children and adults (A.G. Renwick (1998) and SCCS (2018)). Scheuplein et al. (2002) estimate that an uncertainty factor of 10 applied to this intra-species variability is a sufficiently powerful parameter to take into account child/adult variability, for children over 6 months old. This estimate may not be relevant for children under 6 months of age, in the absence of developmental or systemic toxicity studies. Given the ambiguity of these data, the question was raised whether the use of an increased uncertainty/safety factor would be relevant to cover children at birth exposure to cosmetic ingredients and ensure their safety under normal and reasonably foreseeable conditions of use.

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  • In silico prediction of Structure and compound affinity of Multidrug Resistance-associated Protein 2 (MRP2) for predicting hepatotoxicity.

    3/15/19

    MRP2 is an unidirectional efflux transporter mainly present in liver, that primarily transports organic anions, including drug conjugates and conjugated bilirubin. MRP2 supports a function in the terminal excretion and detoxification of endogenous and xenobiotic organic anions. Due to the lack of a X-ray structure of MRP2, there is no detail information about interaction of compounds with MRP2.

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  • Safety assessment of cosmetic ingredients for skin sensitization using QSAR in silico tool

    3/15/19

    Skin sensitization methods are developed to protect workers and consumers from chemical exposures. In 2012, OECD Test Guideline 168 (TG) addressed the 5 Key Events (KE) of the skin sensitization Adverse Outcome Pathway (AOP)[1]. To respond to cellular and tissue events(KE2, KE3) in vitro alternative methods were well described such as OECD TG 442C (Direct Peptide Reactivity Assay, DPRA); OECD TG 442D (KeratinoSens™) and OECD TG 442E (human Cell Line Activation Test, h-CLAT). The two biomarkers based test SENS-IS and the Genomic Allergic Detection Test (GARD) are under consideration by the OECD for the development of the respective TGs.

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  • Essential oils mixtures safety-in-use evaluation in personal care products

    2/11/19

    Essentials oil are defined as complex natural substances. Their composition varies according to the geographical origin of the plant, the part of the plant used, the conditions of production or the method of production. The number of components present in these volatile oils can be very high, despite a structural variation rather limited (3 major atoms: carbon, hydrogen and oxygen). All these characteristics justify the difficulty of carrying out a reliable and relevant toxicological assessment of these ingredients, which are very popular in cosmetic industry. Thanks to chromatographic methods, it is now possible to know the nature and concentration of all the compounds present in an essential oils mixture. Thus, trhough analysis reports obtained by chromatography, the maximum acceptable concentration of a mixture for a given finished cosmetic product can be determined on the basis of the compound identified as limiting. The toxicological approach here applied is mainly based on the QRA methodology (*Qualitative Risk Assessment*) used for the calculation of IFRA certificates. Each compound identified by chromatography has a toxicity reference value (TRV) and a theoretical skin absorption rate. In the absence of TRV, the Threshold of Toxicological Concern approach (TTC - Cramer) will be applied.

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